HCSGD entry for ADA

1. General information

Official gene symbolADA
Entrez ID100
Gene full nameadenosine deaminase
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001666Response to hypoxiaIDAbiological_process
GO:0001821Histamine secretionIEAbiological_process
GO:0001829Trophectodermal cell differentiationIEAbiological_process
GO:0001883Purine nucleoside bindingIEAmolecular_function
GO:0001889Liver developmentIEAbiological_process
GO:0001890Placenta developmentIEAbiological_process
GO:0002314Germinal center B cell differentiationIEAbiological_process
GO:0002636Positive regulation of germinal center formationIEAbiological_process
GO:0002686Negative regulation of leukocyte migrationIEAbiological_process
GO:0002906Negative regulation of mature B cell apoptotic processIEAbiological_process
GO:0004000Adenosine deaminase activityIDA ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005615Extracellular spaceIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005764LysosomeIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006144Purine nucleobase metabolic processTASbiological_process
GO:0006154Adenosine catabolic processIDA ISSbiological_process
GO:0006157Deoxyadenosine catabolic processIEAbiological_process
GO:0007155Cell adhesionIEAbiological_process
GO:0007568AgingIEAbiological_process
GO:0008270Zinc ion bindingIMP ISSmolecular_function
GO:0009168Purine ribonucleoside monophosphate biosynthetic processIEAbiological_process
GO:0009897External side of plasma membraneIDAcellular_component
GO:0009986Cell surfaceIDAcellular_component
GO:0010460Positive regulation of heart rateIEAbiological_process
GO:0016020MembraneIDAcellular_component
GO:0019239Deaminase activityIEAmolecular_function
GO:0030054Cell junctionIEAcellular_component
GO:0030890Positive regulation of B cell proliferationIEAbiological_process
GO:0032261Purine nucleotide salvageIMPbiological_process
GO:0032839Dendrite cytoplasmIEAcellular_component
GO:0033089Positive regulation of T cell differentiation in thymusIEAbiological_process
GO:0033197Response to vitamin EIEAbiological_process
GO:0033632Regulation of cell-cell adhesion mediated by integrinIDAbiological_process
GO:0042110T cell activationIDAbiological_process
GO:0042323Negative regulation of circadian sleep/wake cycle, non-REM sleepIEAbiological_process
GO:0042542Response to hydrogen peroxideIEAbiological_process
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043101Purine-containing compound salvageTASbiological_process
GO:0043103Hypoxanthine salvageIBAbiological_process
GO:0043278Response to morphineIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045987Positive regulation of smooth muscle contractionIEAbiological_process
GO:0046061DATP catabolic processIEAbiological_process
GO:0046103Inosine biosynthetic processIDA ISSbiological_process
GO:0046111Xanthine biosynthetic processIEAbiological_process
GO:0046638Positive regulation of alpha-beta T cell differentiationIEAbiological_process
GO:0048286Lung alveolus developmentIEAbiological_process
GO:0048541Peyer's patch developmentIEAbiological_process
GO:0048566Embryonic digestive tract developmentIEAbiological_process
GO:0050728Negative regulation of inflammatory responseIEAbiological_process
GO:0050850Positive regulation of calcium-mediated signalingIEAbiological_process
GO:0050862Positive regulation of T cell receptor signaling pathwayIEAbiological_process
GO:0055086Nucleobase-containing small molecule metabolic processTASbiological_process
GO:0060169Negative regulation of adenosine receptor signaling pathwayIDAbiological_process
GO:0060205Cytoplasmic membrane-bounded vesicle lumenIEAcellular_component
GO:0060407Negative regulation of penile erectionIEAbiological_process
GO:0070244Negative regulation of thymocyte apoptotic processIEAbiological_process
GO:0070256Negative regulation of mucus secretionIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.45965185210.16542951260.99999024730.7871059653

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0508092516
GSE13712_SHEARDown-0.4431816109
GSE13712_STATICUp0.1408643690
GSE19018Up0.4690167947
GSE19899_A1Down-0.3397325821
GSE19899_A2Down-0.2872143221
PubMed_21979375_A1Down-0.1856403298
PubMed_21979375_A2Up0.0176580318
GSE35957Down-0.1792046351
GSE36640Up0.4748079469
GSE54402Down-0.1141682415
GSE9593Up0.2210387503
GSE43922Down-0.1286751701
GSE24585Down-0.5192234868
GSE37065Up0.0450165312
GSE28863_A1Up0.2109755547
GSE28863_A2Up0.3430378224
GSE28863_A3Down-0.3831069302
GSE28863_A4Up0.1290243489
GSE48662Down-0.0850367570

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-98-5pMIMAT0000096MIRT027685MicroarrayFunctional MTI (Weak)19088304
hsa-miR-484MIMAT0002174MIRT041891CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23209284The ADAR1 (adenosine deaminase acting on RNA1) gene was overexpressed in Bcl6-deficient cells, and its promoter analysis revealed that ADAR1 is a molecular target of Bcl6
2383922S-adenosylhomocysteine hydrolase and adenosine deaminase activities in human red cell ageing
2383922The enzyme activities of S-adenosylhomocysteine hydrolase, adenosine deaminase and pyruvate kinase were determined in normal human erythrocytes subpopulations of different ages separated by centrifugation on a discontinuous Percoll:NaCl density gradient
2383922Adenosine deaminase activities were, however, less critically dependent on erythrocyte age
311477Purine excretion by mouse peritoneal macrophages lacking adenosine deaminase activity
311477Deoxyadenosine, a cytotoxic purine nucleoside, is excreted in large amounts by patients with severe combined immunodeficiency disease associated with deficiency of adenosine deaminase (adenosine aminohydrolase, EC 3
311477However, in the presence of deoxycoformycin, a potent inhibitor of adenosine deaminase, these macrophages also excreted deoxyadenosine
311477A hypothesis is proposed that macrophages of the reticuloendothelial system are a source of deoxyadenosine, which is one of the two cytotoxic purine nucleosides (the other is adenosine) apparently responsible for the suppression of immune functions in patients with adenosine deaminase deficiency
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