Various anti-ageing interventions have been demonstrated to extend the lifespan of model organisms ranging from nematodes to fruit flies to rodents. The interventions have mainly included calorie restriction (CR), genetic manipulations and pharmaceutical administration. However, whether these interventions extend the lifespan via universal or distinct patterns remains unclear. And we found that different shift patterns exists among different anti-ageing interventions. For example, salicylic acid, ks61 and N2 GD1 extends lifespan through different improvement shape. Therefore, we hypothesis that different anti-ageing interventions may extend lifespan in different patterns. Here, we conduct a comparative meta-analysis of numerous published studies on Caenorhabditis elegans and Drosophila. We found that CR and genetic manipulations are generally more effective than medications at extending the total lifespan in both models, and CR can improve the ageing pattern of C. elegans. We further analysed the survival variation for different anti-ageing medications and determined that hypoglycaemic agents and antioxidants are advantageous despite only moderately increasing the overall lifespan; therefore, these two types of medications are promising CR mimetics. Analysis of genetic manipulations also indicated that the genes or pathways that extend lifespan in a healthier pattern are associated with CR. These results suggest that CR or CR mimetics may be the most reasonable and potentially beneficial anti-ageing strategy.

Figure: Schematic diagram of the cluster features. (A-C) Different anti-ageing effect patterns (e.g. salicylic acid :sharp improvement,ks61:slow improvement, N2 GD1:parallel improvement D Size improvement E anti-ageing type features. F Boxplot of the visualized features of resveratrol and other treatments in C.elegans, demonstrating the survival curves generated using identical factors have similar features.

Paper link: Liang, Y., Liu, C., Lu, M., Dong, Q., Wang, Z., Wang, Z., ... & Wang, X. (2018). Calorie restriction is the most reasonable anti-ageing intervention: a meta-analysis of survival curves. Scientific reports, 8(1), 5779.

2018-05-06 08:22:15.0

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